Publications

2016 2015 2014 2013 2012 2011  2010 2009 2008 2007 2006 2005 2004

 

2016

Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JSK, et al (2016). Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol, Dec 2016. 

Staley LA, Ebbert MTW, Bunker D, Bailey M, for the Alzheimer's Disease Neuroimaging Initiative, Ridge PG, Goate AM, Kauwe JSK (2016). Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels. BMC Genomics, 17(Suppl 3):439, June 2016.

Hippen AA, Ebbert MTW, Norton MC, Tschan JT, Munger RG, Corcoran CD, Kauwe JSK (2016). Presenilin E318G variant and Alzheimer's disease risk: the Cache County study. BMC Genomics, 17(Suppl 3):438, June 2016.

Ebbert MTW, Staley LA, Parker J, Parker S, Bailey M, for the Alzheimer's Disease Neuroimaging Initiative, Ridge PG, Goate AM, Kauwe JSK (2016). Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels. BMC Genomics, 17(Suppl 3):437, June 2016.

Staley LA, Ebbert MTW, Parker S, Bailey M, for the Alzheimer's Disease Neuroimaging Initiative, Ridge PG, Goate AM, Kauwe JSK (2016). Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid. BMC Genomics, 17(Suppl 3):436, June 2016.

Kauwe JSK, Goate AM (2016). Genes for a 'Wellderly' Life. Trends in Molecular Medicine. DOI: 10.1016/j.molmed.2016.05.011

Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J; ARUK Consortium, Morgan K, PowellJF, Kauwe JSK, Cruchaga C, Bras J, Goate AM, Singleton AB, Guerreiro R, Hardy J. (2016). Influence of Coding Variability in APP-Aβ MetabolismGenes in Sporadic Alzheimer's Disease. Neurobiology of Aging, PLoS ONE 11(6): e0150079. doi:10.1371/journal.pone.0150079 

Mez J, Mukherjee S, Thornton T, Fardo DW, Trittschuh E, Sutti S, Sherva R, Kauwe JSK, Naj AC, Beecham GW, Gross A, Saykin AJ, Green RC, Crane PK (2016): The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiology of Aging, May 2016, 41, 115-121.

Chen T, Moore TM, Ebbert MTW, McVey NL, Madsen SR, Hallowell DM, Harris AM, Char RE, Mackay RP, Hancock CR, Hansen JM, Kauwe JSK, Thomson DM (2016): Liver kinase B1 inhibits the expression of inflammation-related genes postcontraction in skeletal muscle. Journal of Applied Physiology, April 15, 2016. Vol 120, no. 8, 876-888.

Allen GI, Amoroso N, Anghel C, Balagurusamy V, Bare CJ, Beaton D, Bellotti R, Bennett DA, Boehme K, Boutros PC, Caberlotto L, et al. (2016): Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimer's & Dementia, April 2016.

Oldoni E, Fumagalli GG, Serpente M, Fenoglio C, Scarioni M, Arighi A, Bruno G, Talarico G, ​et al.​ PRNP P39L Variant is a Rare Cause of Frontotemporal Dementia in Italian Population.​ ​J Alzheimers Dis. ​Jan 6, 2016. 50(2):353-357. 

Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane P, Haines JL., Mayeux R, Farrer L, Pericak-Vance MA., Schellenberg GD., Kauwe JSK (2016): Assessment of Genetic Variance of late-onset Alzheimer’s disease. Neurobiology of Aging, 1-8. 


Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D et al. (2016) A potential endophenotype for Alzheimer’s disease: cerebrospinal fluid clusterin. Neurobiology of aging 2016, 37, 208. E1-208. E9.


2015 Return to Top of Page

Mukherjee S, Walter S, Kauwe JS, Saykin AJ, Bennett DA, Larson EB, et al. (2015) Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses. Alzheimer's and Dementia pii: S1552-5260(15)00184-3. doi: 10.1016/j.jalz.

Shah DJ, Rohlfing F, Anand S, Johnson WE, Alvarez MT, Cobell J, King J, Young SA, Kauwe JS, Graves SW (2015): Discovery and Subsequent Confirmation of Novel Serum Biomarkers Diagnosing Alzheimer’s Disease. J Alzheimers Dis. 2015.

Ebbert MTW, Boehme KL, Wadsworth ME, Staley LA, Mukherjee S et al (2015): Interaction between variants in CLU and MS4A4E modulates Alzheimer’s disease risk. Alzheimer’s & Dementia 2015.

Perry CE, Gale SD, Erickson L, Wilson E, Nielsen B, Kauwe J (2015): Seroprevalence and Serointensity of Latent Toxoplasma gondii in a Sample of Elderly Adults With and Without Alzheimer Disease. Alzheimer disease and associated disorders 2015.

Wang L, Naj AC, Graham RR, et al. (2015) Rarity of the Alzheimer Disease–Protective APP A673T Variant in the United StatesJAMA Neurol. 72(2):209-216. doi:10.1001/jamaneurol.2014.2157.

Saykin AJ, Shen L, Yao X, et. al. (2015) Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans. Alzheimer's and Dementia 11: 792-814.

International Genomics of Alzheimer’s Disease Consortium (IGAP). (2015) Convergent genetic and expression data implicate immunity in Alzheimer’s diseaseAlzheimer's and Dementia 11: 658-671. 

Ostergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, et al. (2015) Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study. PLoS Med 12(6): e1001841. doi:10.1371/ journal.pmed.1001841.

Ebbert MTW, Ridge PG, Kauwe JSK (2015) Bridging the Gap between Statistical and Biological Epistasis in Alzheimer’s Disease. Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 870123, 7 pages http://dx.doi.org/10.1155/2015/870123.

Jun G, Ibrahim-Verbals CA, Vronskaya M, Lambert JC, Chung J, Naj AC, et al. (2015) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry. doi: 10.1038/mp.2015.23.

Malik M, Chiles J, Xi HS, Medway C, Simpson J, Potluri S, Howard D et al (2015)Genetics of CD33 in Alzheimer’s disease and acute myeloid leukemia. Human Molecular Genetics 2015ddv092.


2014 Return to Top of Page


Kauwe JSK, Bailey MH, Ridge PG, Perry R, Wadsworth ME, et al. (2014) 
Genome-Wide Association Study of CSF Levels of 59 Alzheimer’s Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation. PLoS Genet 10(10): e1004758. doi:10.1371/journal. pgen.1004758 

Allen M, Kachadoorian M, Quicksall Z, Zou F, Chai HS, Younkin C, Crook JE, Pankratz VS, Carrasquillo MM, Krishnan S
 et alAssociation of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levelsAlzheimer's research & therapy 2014, 6(4):39.

Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J et alMissense variant in TREML2 protects against Alzheimer's diseaseNeurobiol Aging 2014, 35(6):1510 e1519-1526.

Cao Y, Wei P, Bailey M, Kauwe JS, Maxwell TJ, Alzheimer's Disease Neuroimaging I: A versatile omnibus test for detecting mean and variance heterogeneityGenetic epidemiology 2014, 38(1):51-59.

Cruchaga C, Ebbert MT, Kauwe JS: Genetic discoveries in AD using CSF amyloid and tauCurrent genetic medicine reports 2014, 2(1):23-29.

Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S et alRare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature 2014, 505(7484):550-554.

Dayton P, Feilmeier M, Hirschi J, Kauwe M, Kauwe JS: Observed changes in radiographic measurements of the first ray after frontal plane rotation of the first metatarsal in a cadaveric foot modelThe Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 2014, 53(3):274-278.

Dayton P, Kauwe M, Kauwe JS, Feilmeier M, Hirschi J: Observed changes in first metatarsal and medial cuneiform positions after first metatarsophalangeal joint arthrodesisThe Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 2014, 53(1):32-35.

Ebbert MT, Ridge PG, Wilson AR, Sharp AR, Bailey M, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Kauwe JS: Population-based analysis of Alzheimer's disease risk alleles implicates genetic interactionsBiological psychiatry 2014, 75(9):732-737.

Ebbert MT, Wadsworth ME, Boehme KL, Hoyt KL, Sharp AR, O'Fallon BD, Kauwe JS, Ridge PG: Variant Tool Chest: an improved tool to analyze and manipulate variant call format (VCF) filesBMC bioinformatics 2014, 15 Suppl 7:S12.

Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A et alGene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PloS one 2014, 9(6):e94661.

Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC et alPhosphorylated tau-Abeta42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluidBiological psychiatry 2014, 75(9):723-731.

Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C et al: Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and InflammationPLoS genetics 2014, 10(10):e1004758.

Lythgoe C, Perkes A, Peterson M, Schmutz C, Leary M, Ebbert MT, Ridge PG, Norton MC, Tschanz JT, Munger RG et alPopulation-based analysis of cholesteryl ester transfer protein identifies association between I405V and cognitive decline: the Cache County StudyNeurobiol Aging 2014.

Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS et alEffects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study. JAMA neurology 2014.

Peterson D, Munger C, Crowley J, Corcoran C, Cruchaga C, Goate AM, Norton MC, Green RC, Munger RG, Breitner JC et alVariants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study.Alzheimer's & dementia : the journal of the Alzheimer's Association 2014, 10(3):366-371.

Ridge PG, Maxwell TJ, Foutz SJ, Bailey MH, Corcoran CD, Tschanz JT, Norton MC, Munger RG, O'Brien E, Kerber RA et alMitochondrial genomic variation associated with higher mitochondrial copy number: the Cache County Study on Memory Health and AgingBMC bioinformatics 2014, 15 Suppl 7:S6.

Sharp AR, Ridge PG, Bailey MH, Boehme KL, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Kauwe JS, Alzheimer's Disease Neuroimaging I: Population substructure in Cache County, Utah: the Cache County studyBMC bioinformatics 2014, 15 Suppl 7:S8.

Shen L, Thompson PM, Potkin SG, Bertram L, Farrer LA, Foroud TM, Green RC, Hu X, Huentelman MJ, Kim S et al: Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkersBrain imaging and behavior 2014, 8(2):183-207.

Gross AL, Sherva R, Mukherjee S, Newhouse S, Kauwe JS, Munsie LM, Waterston LB, Bennett DA, Jones RN, Green RC et alCalibrating Longitudinal Cognition in Alzheimer's Disease Across Diverse Test Batteries and DatasetsNeuroepidemiology 2014, 43(3-4):194-205.


2013
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Chapman, J., E. Rees, D. Harold, D. Ivanov, A. Gerrish, R. Sims, P. Hollingworth, A. Stretton, Genetic and Environmental Risk for Alzheimer's Disease Consortium (Kauwe J.S.K. and others), P. Holmans, M.J. Owen, M.C. O'Donovan, J. Williams, and G. Kirov, A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk. Hum Mol Genet, 2013. 22(4): p. 816-24.

Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S et alRare coding variants in the phospholipase D3 gene confer risk for Alzheimer's diseaseNature 2013.

*Cruchaga, C., *J.S.K. Kauwe, O. Harari, S.C. Jin, Y. Cai, C.M. Karch, B.A. Benitez, A.T. Jeng, T. Skorupa, D Carrell, S. Bertelsen, M. Bailey, D. McKean, J.M. Shulman, P.L. De Jager, L. Chibnik, D.A. Bennett, S.E. Arnold, D. Harold, R. Sims, A. Gerrish, J. Williams, V.M. Van Deerlin, V.M. Lee, L.M. Shaw, J.Q. Trojanowski, J.L. Haines, R. Mayeux, M.A. Pericak-Vance, L.A. Farrer, G.D. Schellenberg, E.R. Peskind, D. Galasko, A.M. Fagan, D.M. Holtzman, J.C. Morris, G. Consortium, I. Alzheimer's Disease Neuroimaging, C. Alzheimer Disease Genetic, and A.M. Goate, GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron, 2013. 78(2): p. 256-68.

Gonzalez, J., C. Schmutz, C. Munger, A. Perkes, A. Gustin, M. Peterson, E. M.T.W., M.C. Norton, J.T. Tschanz, R.G. Munger, C.D. Corcoran, and J.S.K. KauweAssessment of TREM2 R47H association with Alzheimer's disease in a population-based sample: The Cache County Study. Neurobiology of Aging,  2013, 34(12):2889 e2811-2883.

Guerreiro, R., A. Wojtas, J. Bras, M. Carrasquillo, E. Rogaeva, E. Majounie, C. Cruchaga, C. Sassi, J.S.K. Kauwe, S. Younkin, L. Hazrati, J. Collinge, J. Pocock, T. Lashley, J. Williams, J.C. Lambert, P. Amouyel, A. Goate, R. Rademakers, K. Morgan, J. Powell, P. St George-Hyslop, A. Singleton, J. Hardy, and G. Alzheimer Genetic AnalysisTREM2 variants in Alzheimer's disease. N Engl J Med, 2013. 368(2): p. 117-27.

Kauwe JS, Ridge PG, Foster NL, Cannon-Albright LA: Strong evidence for a genetic contribution to late-onset Alzheimer's disease mortality: a population-based study. PloS one 2013, 8(10):e77087.

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B et alMeta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature genetics 2013, 45(12):1452-1458.

Lee SH, Harold D, Nyholt DR, Consortium AN, International Endogene C, Genetic, Environmental Risk for Alzheimer's disease C, Goddard ME, Zondervan KT, Williams J et alEstimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosisHuman molecular genetics 2013, 22(4):832-841.

Ridge, P.G., Ebbert, M.T.W., and J.S.K. KauweGenetics of Alzheimer's disease. BioMed Research International, 2013, 2013:254954.

Ridge PG, Koop A, Maxwell TJ, Bailey MH, Swerdlow RH, Kauwe JS, Honea RA, Alzheimer's Disease Neuroimaging I: Mitochondrial haplotypes associated with biomarkers for Alzheimer's disease. PloS one 2013, 8(9):e74158.

Ridge PG, Mukherjee S, Crane PK, Kauwe JSK, Alzheimer’s Disease Genetics C: Alzheimer’s Disease: Analyzing the Missing Heritability. PloS one 2013, 8(11):e79771.


2012 Return to Top of Page

Cruchaga, C., J.S.K. Kauwe, P. Nowotny, K. Bales, E.H. Pickering, K. Mayo, S. Bertelsen, A. Hinrichs, I. Alzheimer's Disease Neuroimaging, A.M. Fagan, D.M. Holtzman, J.C. Morris, and A.M. Goate, Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Hum Mol Genet, 2012. 21(20): p. 4558-71.

Gerrish, A., G. Russo, A. Richards, V. Moskvina, D. Ivanov, D. Harold, R. Sims, R. Abraham, P. Hollingworth, J. Chapman, M. Hamshere, J.S.K. Pahwa, K. Dowzell, A. Williams, N. Jones, C. Thomas, A. Stretton, A.R. Morgan, S. Lovestone, J. Powell, P. Proitsi, M.K. Lupton, C. Brayne, D.C. Rubinsztein, M. Gill, B. Lawlor, A. Lynch, K. Morgan, K.S. Brown, P.A. Passmore, D. Craig, B. McGuinness, S. Todd, J.A. Johnston, C. Holmes, D. Mann, A.D. Smith, S. Love, P.G. Kehoe, J. Hardy, S. Mead, N. Fox, M. Rossor, J. Collinge, W. Maier, F. Jessen, H. Kolsch, R. Heun, B. Schurmann, H. van den Bussche, I. Heuser, J. Kornhuber, J. Wiltfang, M. Dichgans, L. Frolich, H. Hampel, M. Hull, D. Rujescu, A.M. Goate, J.S.K. Kauwe, C. Cruchaga, P. Nowotny, J.C. Morris, K. Mayo, G. Livingston, N.J. Bass, H. Gurling, A. McQuillin, R. Gwilliam, P. Deloukas, G. Davies, S.E. Harris, J.M. Starr, I.J. Deary, A. Al-Chalabi, C.E. Shaw, M. Tsolaki, A.B. Singleton, R. Guerreiro, T.W. Muhleisen, M.M. Nothen, S. Moebus, K.H. Jockel, N. Klopp, H.E. Wichmann, M.M. Carrasquillo, V.S. Pankratz, S.G. Younkin, L. Jones, P.A. Holmans, M.C. O'Donovan, M.J. Owen, and J. Williams, The role of variation at AbetaPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. J Alzheimers Dis, 2012. 28(2): p. 377-87.

Hamilton, G., S.E. Harris, G. Davies, D.C. Liewald, A. Tenesa, A. Payton, M.A. Horan, W.E. Ollier, N. Pendleton, Genetic and Environmental Risk for Alzheimer's Disease Consortium (Kauwe J.S.K. and others), J.M. Starr, D. Porteous, and I.J. Deary, The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk. Am J Med Genet B Neuropsychiatr Genet, 2012. 159B(6): p. 696-709.

Hamilton, G., R. Killick, Genetic and Environmental Risk for Alzheimer's Disease Consortium (Kauwe J.S.K. and others), Translational Genomics Research Institute, J.C. Lambert, P. Amouyel, I. European Alzheimer Disease, M.M. Carrasquillo, V.S. Pankratz, N.R. Graff-Radford, D.W. Dickson, R.C. Petersen, S.G. Younkin, J.F. Powell, and R. Wade-Martins, Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiol Aging, 2012. 33(8): p. 1848 e1-13.

Hollingworth, P., R. Sweet, R. Sims, D. Harold, G. Russo, R. Abraham, A. Stretton, N. Jones, A. Gerrish, J. Chapman, D. Ivanov, V. Moskvina, S. Lovestone, P. Priotsi, M. Lupton, C. Brayne, M. Gill, B. Lawlor, A. Lynch, D. Craig, B. McGuinness, J. Johnston, C. Holmes, G. Livingston, N.J. Bass, H. Gurling, A. McQuillin, Genetic and Environmental Risk for Alzheimer's Disease Consortium (Kauwe J.S.K. and others), G. National Institute on Aging Late-Onset Alzheimer's Disease Family Study, P. Holmans, L. Jones, B. Devlin, L. Klei, M.M. Barmada, F.Y. Demirci, S.T. DeKosky, O.L. Lopez, P. Passmore, M.J. Owen, M.C. O'Donovan, R. Mayeux, M.I. Kamboh, and J. Williams, Genome-wide association study of Alzheimer's disease with psychotic symptoms. Mol Psychiatry, 2012. 17(12): p. 1316-27.

Houston, D.D., D.B. Elzinga, P.J. Maughan, S.M. Smith, J.S.K. Kauwe, R.P. Evans, R.B. Stinger, and D.K. Shiozawa, Single nucleotide polymorphism discovery in cutthroat trout subspecies using genome reduction, barcoding, and 454 pyro-sequencing. BMC Genomics, 2012. 13: p. 724.

Hudson, G., R. Sims, D. Harold, J. Chapman, P. Hollingworth, A. Gerrish, G. Russo, M. Hamshere, V. Moskvina, N. Jones, C. Thomas, A. Stretton, P.A. Holmans, M.C. O'Donovan, M.J. Owen, J. Williams, P.F. Chinnery, and Genetic and Environmental Risk for Alzheimer's Disease Consortium (Kauwe J.S.K. and others). No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology, 2012. 78(14): p. 1038-42.

Jun, G., B.N. Vardarajan, J. Buros, C.E. Yu, M.V. Hawk, B.A. Dombroski, P.K. Crane, E.B. Larson, Alzheimer's Disease Genetics Consortium (Kauwe J.S.K. and others), R. Mayeux, J.L. Haines, K.L. Lunetta, M.A. Pericak-Vance, G.D. Schellenberg, and L.A. FarrerComprehensive search for Alzheimer disease susceptibility loci in the APOE region. Arch Neurol, 2012. 69(10): p. 1270-9.

Ridge, P.G., T.J. Maxwell, C.D. Corcoran, M.C. Norton, J.T. Tschanz, E. O'Brien, R.A. Kerber, R.M. Cawthon, R.G. Munger, and J.S.K. Kauwe,Mitochondrial genomic analysis of late onset Alzheimer's disease reveals protective haplogroups H6A1A/H6A1B: the Cache County Study on Memory in Aging. PLoS One, 2012. 7(9): p. e45134.

Shi, H., O. Belbin, C. Medway, K. Brown, N. Kalsheker, M. Carrasquillo, P. Proitsi, J. Powell, S. Lovestone, A. Goate, S. Younkin, P. Passmore, Genetic and Environmental Risk for Alzheimer's Disease Consortium (Kauwe J.S.K. and others), K. Morgan, and U.K.C. Alzheimer's Research,Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiol Aging, 2012. 33(8): p. 1849 e5-18.

Zou, F., H.S. Chai, C.S. Younkin, M. Allen, J. Crook, V.S. Pankratz, M.M. Carrasquillo, C.N. Rowley, A.A. Nair, S. Middha, S. Maharjan, T. Nguyen, L. Ma, K.G. Malphrus, R. Palusak, S. Lincoln, G. Bisceglio, C. Georgescu, N. Kouri, C.P. Kolbert, J. Jen, J.L. Haines, R. Mayeux, M.A. Pericak-Vance, L.A. Farrer, G.D. Schellenberg, Alzheimer's Disease Genetics Consortium (Kauwe J.S.K. and others), R.C. Petersen, N.R. Graff- Radford, D.W. Dickson, S.G. Younkin, and N. Ertekin-Taner, Brain expression genome- wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet, 2012. 8(6): p. e1002707. 


2011 Return to Top of Page

Cruchaga C, Nowotny P, Kauwe JS, Ridge PG, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC et alAssociation and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease. Archives of neurology 2011, 68(8):1013-1019.

Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V et alCommon variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature genetics 2011, 43(5):429-435.

Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM et alFine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. PloS one 2011, 6(2):e15918.

Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK et alCommon variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature genetics 2011, 43(5):436-441.

Overton ET, Kauwe JS, Paul R, Tashima K, Tate DF, Patel P, Carpenter CC, Patty D, Brooks JT, Clifford DB: Performances on the CogState and standard neuropsychological batteries among HIV patients without dementia. AIDS and behavior 2011, 15(8):1902-1909.

2010 Return to Top of Page

Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D et alSNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. PLoS genetics 2010, 6(9):e1001101.

Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R et alGenetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PloS one 2010, 5(11):e13950.

Kauwe JS, Bertelsen S, Mayo K, Cruchaga C, Abraham R, Hollingworth P, Harold D, Owen MJ, Williams J, Lovestone S et alSuggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010, 153B(4):955-959.

Kauwe JS, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, Hinrichs AL, Fagan AM, Holtzman DM, Alzheimer's Disease Neuroimaging I et alValidating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. Journal of Alzheimer's disease : JAD 2010, 21(3):833-842.


2009 Return to Top of Page

Clifford DB, Fagan AM, Holtzman DM, Morris JC, Teshome M, Shah AR, Kauwe JS: CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease. Neurology 2009, 73(23):1982-1987.

Fenoglio C, Galimberti D, Cortini F, Kauwe JS, Cruchaga C, Venturelli E, Villa C, Serpente M, Scalabrini D, Mayo K et alRs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD 2009, 18(3):603-612.

Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A et alGenome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature genetics 2009, 41(10):1088-1093.

Kauwe JS, Wang J, Mayo K, Morris JC, Fagan AM, Holtzman DM, Goate AM: Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Neurogenetics  2009, 10(1):13-17.


2008 Return to Top of Page

Kauwe JS, Cruchaga C, Mayo K, Fenoglio C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Morris JC, Fagan AM et al: Variation in MAPT is 
associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition
. 
Proceedings of the National Academy of Sciences 
of the United States of America 
2008, 105(23):8050-8054.

Kauwe JS, Wang J, Chakraverty S, Goate AM, Henao-Martinez AF: Novel presenilin 1 variant (P117A) causing Alzheimer's disease in the fourth 
decade of life
. Neuroscience letters 2008, 438(2):257-259.

Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH et al: Molecular characterization 
of novel progranulin (GRN) mutations in frontotemporal dementia
. Human mutation 2008, 29(4):512-521.

2007 Return to Top of Page

Hu Y, Hosseini A, Kauwe JS, Gross J, Cairns NJ, Goate AM, Fagan AM, Townsend RR, Holtzman DM: Identification and validation of novel CSF 
biomarkers for early stages of Alzheimer's disease
. Proteomics Clinical applications 2007, 1(11):1373-1384.

Kauwe JS, Jacquart S, Chakraverty S, Wang J, Mayo K, Fagan AM, Holtzman DM, Morris JC, Goate AM: Extreme cerebrospinal fluid amyloid beta 
levels identify family with late-onset Alzheimer's disease presenilin 1 mutation
. Annals of neurology 2007, 61(5):446-453.

Mukherjee O, Kauwe JS, Mayo K, Morris JC, Goate AM: Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease. 
BMC genetics 2007, 8:3.

Nowotny P, Bertelsen S, Hinrichs AL, Kauwe JS, Mayo K, Jacquart S, Morris JC, Goate A: Association studies between common variants in prolyl 
isomerase Pin1 and the risk for late-onset Alzheimer's disease
. Neuroscience letters 2007, 419(1):15-17.

Nowotny P, Simcock X, Bertelsen S, Hinrichs AL, Kauwe JS, Mayo K, Smemo S, Morris JC, Goate A: Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP). American journal of medical genetics Part B, 
Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 
2007, 144B(4):469-474.

Wahrle SE, Shah AR, Fagan AM, Smemo S, Kauwe JS, Grupe A, Hinrichs A, Mayo K, Jiang H, Thal LJ et al: Apolipoprotein E levels in cerebrospinal fluid 
and the effects of ABCA1 polymorphisms
. 
Molecular neurodegeneration 2007, 2:7.

2006 Return to Top of Page

Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L et al: A scan of chromosome 10 identifies a novel 
locus showing strong association with late-onset Alzheimer disease
. 
American journal of human genetics 2006, 78(1):78-88.

Li Y, Grupe A, Rowland C, Nowotny P, Kauwe JS, Smemo S, Hinrichs A, Tacey K, Toombs TA, Kwok S et al: DAPK1 variants are associated with 
Alzheimer's disease and allele-specific expression
. Human molecular genetics 2006, 15(17):2560-2568.

Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J et alHDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Annals 
of neurology 
2006, 60(3):314-322.

Smemo S, Nowotny P, Hinrichs AL, Kauwe JS, Cherny S, Erickson K, Myers AJ, Kaleem M, Marlowe L, Gibson AM et alUbiquilin 1 polymorphisms are 
not associated with late-onset Alzheimer's disease
. Annals of neurology 2006, 59(1):21-26.

2005 Return to Top of Page

Dunn G, Hinrichs AL, Bertelsen S, Jin CH, Kauwe JS, Suarez BK, Bierut LJ: Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures. BMC genetics 2005, 6 Suppl 1:S122.

Hinrichs AL, Bertelsen S, Bierut LJ, Dunn G, Jin CH, Kauwe JS, Suarez BK: Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps. BMC genetics 2005, 6 Suppl 1:S34.

Kauwe JS, Bertelsen S, Bierut LJ, Dunn G, Hinrichs AL, Jin CH, Suarez BK: The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure. BMC genetics 2005, 6 Suppl 1:S84.

Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell T, Holmans P, Hamshere M, Turic D, Jehu L, Hollingworth P et alAssociation studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005, 136B(1):62-68.

Suarez BK, Taylor C, Bertelsen S, Bierut LJ, Dunn G, Jin CH, Kauwe JS, Paterson AD, Hinrichs AL: An analysis of identical single-nucleotide polymorphisms genotyped by two different platforms. BMC genetics 2005, 6 Suppl 1:S152.


2004 Return to Top of Page

Kauwe JSK, Shiozawa DK, Evans RP: Phylogeographic and nested clade analysis of the stonefly Pteronarcys californica (Plecoptera : Pteronarcyidae) in the western USA. J N Am Benthol Soc 2004, 23(4):824-838.

Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL, Tacey K, Doil L, van Luchene R, Garcia V et alAssociation of late-onset Alzheimer's 
disease with genetic variation in multiple members of the GAPD gene family
. Proceedings of the National Academy of Sciences of the United States of America 2004, 101(44):15688-15693.